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Yes, you most probably can.

This is how you would do it on a Windows machine:

In LO Writer go to the Tools menu and choose Extension Manager. Click Add in the Extension Manager window, navigate to the folder : Program Files\EndNote X5\Product-Support\CWYW. Select the EndNote.oxt file and click Open. The Endnote extension will now appear in the list. Exit LibreOffice Writer and then restart it. The Endnote X5 toolbar and a new top menu entry named EndNote X5 appears between Tools and Window.

(adapted from http://lists.adeptscience.co.uk/endnote/endnote_Jul_2011/thid_ffc64096d76d7c4de35040e646d2e78c.html)

It worked for me with Endnote X5 and LibreOffice 3.5.5.3 on a Windows XP SP3 machine.

I think it should be pretty similar on a Mac (i.e. find and install the Endnote.oxt extension)