Windows 10 Libreoffice will not run

Good day.
I have looked through the forum but want to restart the conversation to be fresh.
Windows 10
LibreOffice v 6.3.2
Installs just fine.
Open existing LibreOffice Spreadsheet (from USB) and all I get is a white blank window.
Start in Libreoffice safe mode;
I can access a new spreadsheet, but previously created spreadsheet will not open.
All drivers are up to date.
Earlier today, with an older version of Libreoffice it opened fine.
Had a printer issue, reinstalled software, etc.
Now Libre Office will not run.
I can not tell you how much I hate win10
I’ve been is safe mode and ran through ALL, repeat ALL options with no result.
Any help please?
Dave

I will give it a try, because it looks you have two main issues:

  1. Open existing LibreOffice Spreadsheet (from USB) and all I get is a white blank window.

The files on your USB stick could be damaged or there is something not working good with USB on your computer.
Besides that keep in mind that USB sticks have limited lifetime and maybe not so relaible as you think Even my USB 3.0 external harddrive needs more time to wake up after a sleeping period of the computer… And some times it makes a difference putting your stick directly in the computer or in a USB hub…

  1. Had a printer issue, reinstalled software, etc. Now Libre Office will not run.

I can hardly imagine that not running LO has something to do with your printer problems.
But it is of course a USB printer and that reminds me again off a USB problem on your computer.
Make a fresh install of LO and see what happens.

I have 3 computers all running W10 Pro latest version with LO and I have no problems.

Thank you for your effort.
The USB works fine with my Win7 rig.
(Win 10 is laptop btw.)
Printer is running wireless.
I copied files from USB to laptop and no different result.
Uninstalled LO, cleaned registry, went digging and deleted all other LO files deep in AppData, installed LO 5.x.x.x.
LO will not open any files…will open new projects.
LO safe Mode does not have any effect
LO files WILL open in Windows Safe Mode.
But of course I can not print.