Using LO 6.1.0 and Windows 8.1. Is it possible to set up Calc to access one data directory, Writer a second data directory, and Base a third data directory?

This is how I always had my ancient MS Word (2003) set up and I would like to continue the practice if possible. Thanks.

Can you elaborate, please? I want to say “Sure, why not?” but I think “What’s the problem?” would be the better question to ask you.

I have my data directories set up as follows:

D:\Data\Spreadsheet Data
D:\Word Processing Data
D:\Database Data

I have looked but just can’t seem to find where to put these paths into the settings for each application. All I see is one path for all data.

Data directories can usually be created arbitrarily. However, the handling is initially based on the OS. That is not a problem of LibreOffice. Please read the manual of your OS.