In a spreadsheet how do I instruct B2=A2-A1, B3=A3-A2 etc.?

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Exactly! In cell B2, enter =A2-A1. Then Copy it. Now highlight all the cells below B2 in which you want the formula to apply, use menu Edit -> Paste Special. (Do not use simple Paste.) A dialog box appears. Now under Selection, uncheck all the checked boxes, and check only Formulas and Formats. Click OK. Presto!

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Hello,

• Go to cell B2 and enter the formula
• Select cel B2
• Double click the black square in the lower right corner of cell B2

[Update] Changed left to right (thanks to @BigRAl )

Hope that helps.